According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Real defeat Atletico in shootout to reach Champions League quarters
Real Madrid beat city rivals Atletico 4-2 on penalties to reach the Champions League quarter-finals following an enthralling last-16 tie which ended 2-2 after extra time in a raucous atmosphere at Metropolitano on Wednesday.
Sharjah reach AFC Champions League 2 semi-final
Sharjah FC advanced into the AFC Champions League Two semi-finals after defeating Shabab Al Ahli 5-4 on penalties, after their quarter-final second leg tie ended 1-1 on the night after extra time and 2-2 on aggregate on Wednesday.
New boxing world body approves six additional members
World Boxing has increased its membership to 84 countries with China and Turkey, whose athletes won medals in the ring at last year's Paris Olympics, among the latest six to sign up.
Dubai Basketball to tackle Partizan Mozzart Bet at Coca-Cola-Arena
Dubai Basketball are set to take on Partizan Mozzart Bet on March 17 at the Coca-Cola Arena. The game promises to deliver an exciting match-up as Dubai’s first international professional sports franchise faces one of Europe’s most renowned basketball teams.
PSG knock Liverpool out of Champions League in shootout
Paris St Germain beat Liverpool 4-1 in a penalty shootout to advance to the Champions League quarter-finals after winning a rip-roaring last-16 second-leg match at Anfield 1-0 on Tuesday thanks to a goal from Ousmane Dembele.
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It arrived: The UAE's First Mega Music Festival at Expo City Dubai!
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