With almost 14 million followers, Madonna thinks Instagram is designed to "make you feel bad".
The 60-year-old admitted that social media's influence can also be toxic.
"You get caught up in comparing yourself to others. I think Instagram is made to make you feel bad. People are really a slave to winning people's approvals," she explained.
Madonna thinks she's fortunate to have found fame in the pre-internet era.
As a result, the chart-topping singer believes she was given the scope to "develop as an artist and a human without feeling the pressure of judgement of other people".